The histopathology and ultrastructure of tumors induced by simian adenovirus 30.

Cesium chloride-purified preparations of simian adenovirus 30 (SV30) were found to be oneogenic when inoculated into new born hamsters. Subcutaneous tumors developed in low incidence «2 %), and a histopathologic pattern similar to that induced by oneogenic human adenoviruses (25, 37, 51) was described. The neoplasm induced by SV30 and the biologic activity of the virus appear to have notable differences from that reported for SV40 and its corresponding neoplasm. The ultrastructure of these malignant cells revealed them to have relatively undifferentiated cytoplasmic organdÃ-es. Annulate lamellae and virus-like particles with an average diameter of 80 rmt were observed in neoplastic cells. These particles within tumor cells resembled the morphologic appearance characteristic of in fectious simian adenoviruses and displayed "budding" from the